Grapefruit is a delicious and nutritious fruit that is enjoyed by many people around the world. However, grapefruit can interact with certain medications and cause serious side effects. Therefore, it is important to be aware of the potential risks before consuming grapefruit.
Grapefruit juice inhibits an enzyme in the gut called CYP3A4 which is responsible for breaking down many different types of medication in the body1. This can lead to increased blood concentrations of the medication which may cause toxicity and serious side effects. For example, grapefruit juice can increase the blood levels of cholesterol-lowering statins2,3 which may lead to muscle pain and weakness. Additionally, grapefruit juice can increase the blood levels of calcium channel blockers4 which are used to treat high blood pressure and heart conditions. This can lead to an increased risk of low blood pressure and dizziness. Grapefruit juice has also been shown to interact with immunosuppressant medications5 which are used to treat autoimmune diseases such as Crohn’s disease, psoriasis and rheumatoid arthritis. These interactions can cause potentially life-threatening side effects such as liver damage or kidney failure.
In conclusion, grapefruit is a delicious fruit that is enjoyed by many people around the world; however, it is important to be aware of the potential risks before consuming grapefruit. grapefruit juice can interact with certain medications and cause serious side effects. Therefore, it is important to speak with a healthcare professional before consuming grapefruit if you are taking any medications.
5 https://www.ncbi.nlm years_in_businessnaughts 2914709740 / PMC4007517 /